Protein Modification Reagents
Medchemexpress LLC Ald-ph-amido-PEG4-C2-NHS ester | 1353011-74-1 | 98.1% | 494.49 g/mol | C23H30N2O10 | 50 MG
A noncleavable, four-unit polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester functional group designed for antibody-agent conjugation and general bioconjugation applications. The linker provides PEG spacing and a reactive NHS ester for coupling to primary amines; it is supplied as a solid and is intended for research use only.
- Noncleavable 4-unit PEG linker.
- NHS ester reactive toward primary amines.
- Suitable for antibody-agent conjugation and bioconjugation workflows.
- Molecular weight approximately 494.49 g/mol.
- CAS number 1353011-74-1.
Medchemexpress LLC Biotin-PEG1-NH2 | 811442-85-0 | 97.0% | 330.45 g/mol | C14H26N4O3S | 100 MG
Biotin-PEG1-NH2 is a cleavable one-unit polyethylene glycol (PEG) linker bearing a biotin tag and a terminal primary amine (-NH2), designed for use in the synthesis of antibody-drug conjugates (ADCs). Intended for research use only.
- Cleavable 1-unit PEG linker suitable for ADC synthesis.
- Biotin tag for affinity capture or detection.
- Terminal primary amine (-NH2) for conjugation chemistries.
- Purity 97.0%.
- Molecular weight 330.45 g/mol.
- CAS number 811442-85-0.
- Form: white to off-white solid; store protected from light; in solvent: -80°C (6 months), -20°C (1 month).
- Available packaging: 25 MG, 50 MG, 100 MG, 200 MG (quote), 500 MG (quote).
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | >90% | 388.37 g/mol | C15H24N4O8 | 50 MG
N3-PEG4-C2-NHS ester is an azide-functionalized, non-cleavable polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and an azide (N3) group for click chemistry applications such as antibody-drug conjugate (ADC) synthesis and bioconjugation.
- Azide-functionalized 4-unit PEG linker suitable for bioconjugation.
- N-hydroxysuccinimide (NHS) ester for efficient amine coupling.
- Compatible with copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO; stock solutions commonly prepared per datasheet guidance.
- Storage recommendations: pure form -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Dbco-peg4-ggfg-dxd | 2694856-51-2 | MFCD22575025 | 98.4% | 1375.47 | C72H79FN10O17 | 5 MG
DBCO-PEG4-GGFG-Dxd is an agent-linker conjugate used in antibody-drug conjugate (ADC) research that incorporates a cleavable GGFG linker and a DBCO-PEG4 moiety to enable strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry for conjugation to azide-containing molecules.
- Provides a payload-linker suitable for ADC construction.
- Enables copper-free SPAAC click chemistry with azide-functionalized partners.
- Contains a cleavable GGFG linker for payload release.
- Supplied as an off-white to light yellow solid for ease of handling.
- Stable when stored protected from light at -20°C; in solvent stability is extended at -80°C.
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.7% | C17H27BrN2O9 | 50 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Avanti Polar Lipids 14:0 PEG1000 PE
14:0 PEG1000 PE 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] (ammonium salt)
Medchemexpress LLC Azide-PEG5-tos | 236754-49-7 | MFCD28505520 | 98.5% | 417.48 | C17H27N3O7S | 5 G
Azide-PEG5-Tos is a cleavable 5-unit polyethylene glycol (PEG) linker bearing an azide functional group and a tosyl leaving group, designed for click-chemistry conjugations and the synthesis of antibody-drug conjugates and PROTAC linkers.
- cleavable 5-unit peg linker suitable for ADC and PROTAC synthesis.
- azide functional group for CuAAC and SPAAC click reactions.
- high purity suitable for research applications.
- appearance: liquid, colorless to light yellow.
- molecular formula c17h27n3o7s and molecular weight 417.48 g/mol.
- storage: pure form at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months) or -20°C (1 month).
BEZWADA BIOMEDICAL LLC PEG Methacrylate, MW 4000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
BEZWADA BIOMEDICAL LLC PEG Methacrylate, MW 6000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
Broadpharm Fmoc-N-amido-PEG5-acid | 882847-32-7 | MFCD06656473 | 5g
Fmoc-N-amido-PEG5-acid | Putity: 98% | MW: 531.6 | 882847-32-7 | MFCD06656473 | 5g
Bioassay Systems QuantiFluo™ Pepsin Inhibitor Assay Kit, For evaluation of drugs and screening of potential inhibitors to pepsin proteases.
PEPSIN (EC 3.4.23.1) is a digestive, serine protease that hydrolyzes dietary proteins in many eukaryotic and prokaryotic organisms. Pepsin predominantly cleaves peptide chains at the amino side of the aromatic phenylalanine, tryptophan, and tyrosine amino acids. BioAssay Systems’ QuantiFluo™ Pepsin Inhibitor Assay Kit uses a fluorescein isothiocyanate (FITC)-labeled synthetic substrate. The fluorescein label is highly quenched. Upon digestion by pepsin present in the sample, the substrate is cleaved into smaller peptides, which abolishes the quenching of the fluorescence label. The fluorescence or fluorescence polarization (FP) of the FITC-labeled fragments is measured at λex/em = 485/530 nm. Inhibition is determined by the decrease in fluorescence.
Vector Biolabs S-phase kinase-associated protein 2 (p45) Adenovirus (Ad-SKP2)
Cyclin A-Cdk2 kinase activity is essential for progression of the cell through S phase. Skp1 p19 and Skp2 p45 are elements of the cyclin A-Cdk2 S phase kinase. The binding of p19 to cyclin A-Cdk2 is p45-dependent, and levels of p45 are substantially increased in transformed cells. Thus, the modulation of Skp2 p45 expression may result in changes in cell cycle control that contribute to the process of cell transformation.
ABclonal Technology MICU2 Rabbit pAb
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.
Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | 98.0% | 2000 (average) | 50 MG
m-PEG-DMG (MW 2000) is a PEGylated lipid supplied as a powder with an average PEG molecular weight of 2000. It is intended for incorporation into liposomes and lipid nanoparticles for formulation and drug delivery research, providing a PEG surface modification to improve colloidal stability and in vivo circulation.
- PEGylated lipid suitable for liposome and lipid nanoparticle formulation.
- Average molecular weight about 2000 for consistent PEG chain length.
- Enhances particle stability and circulation time in biological systems.
- Supplied as a powder compatible with solvent-based formulation workflows.
- Stable under recommended frozen storage for extended shelf life.